Oral hygiene care and the management of oral symptoms in patients with cancer in palliative care: a mixed methods systematic review protocol.

OBJECTIVE: The objective of this review is to examine the effectiveness of oral hygiene care in the management of oral symptoms in patients with cancer under specialist palliative care and the patients' experience of such symptoms and care. INTRODUCTION: Oral symptoms, such as xerostomia, mouth pain, or dysgeusia, are highly prevalent in patients with cancer under specialist palliative care. These symptoms have a negative effect on patients' quality of life. Oral hygiene care can manage oral symptoms and could be improved with a more systematized approach, adequate guidelines, and training to properly integrate oral hygiene into the care provided in specialist palliative care. INCLUSION CRITERIA: This review will consider quantitative, qualitative, and mixed methods studies on the effectiveness and experience of oral hygiene care intended to manage oral symptoms in patients with cancer aged 18 years or older, diagnosed with any type of cancer, under specialist palliative care. METHODS: The search will be conducted in MEDLINE (PubMed), CINAHL (EBSCOhost), Cochrane Central Register of Controlled Trials, Dentistry and Oral Sciences Source (EBSCOhost), and MedicLatina (EBSCOhost). Sources of unpublished studies and gray literature to be searched will include Networked Digital Library of Theses and Dissertations and Repositórios Científicos de Acesso Aberto de Portugal. Studies in English, Portuguese, and Spanish published from 2000 to the present will be considered. Methodological quality of included studies will be assessed and data will be extracted. Synthesis and integration will follow the JBI segregated approach for mixed methods reviews. REVIEW REGISTRATION: PROSPERO CRD42023400554.

Método para la evaluación de la actividad farmacológica de las prostaglandinas obtenidas en Cuba / A method for assessing the pharmaceutic activity of prostaglandins obtained in Cuba

Se describen las técnicas farmacológicas y los procedimientos estadísticos empleados para evaluar la potencia respectiva de las acciones hipotensora y estimulante de la contractilidad muscular lisa de los distintos tipos de prostaglandinas E, F, A y B. Se exponen conjuntamente los resultados obtenidos en la aplicación de dicho método en la valoración biológica de un lote de PGA2 extraída de gorgonias cubanas de la especie Plexaura homomalla(AU)